This document does not contain all possible interactions. Before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Does Prostin E2 VAGINAL Suppository Suppository interact with other drugs you are taking? Enter your medication into the WebMD interaction checker Check Interaction Overdose This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Notes Use under direct medical supervision. Missed Dose Not applicable. Storage Store in a freezer at or below -4 degrees F (-20 degrees C) away from light and moisture. Bring to room temperature just before use. Keep wrapped in foil until just before use.
Since we employed a cross-sectional design and self-report was used to assess herbal medicine use in this study, there is a possibility of under-reporting or over-reporting of the prevalence of use. Also, it was impossible to establish a trend or a clear causal effect [68]. The possibility that respondent might not have been truthful in their response (social desirability bias) should be considered in our study. In addition, our study fails to look at the reasons why women utilize herbal medicine despite receiving free healthcare service in public health facilities. Further research should look into this area. Further, our study was conducted in an urban and peri-urban setting, which makes findings not generalizable for the whole of Sierra Leone, especially for rural areas.
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In this study, supplementation of MK for 15 days significantly boosted the neurobehavioral outcomes and neuronal defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. The recuperation of the brain from oxidative stress during reperfusion after ischemia was preceded by recovery of GSH with its dependent enzymes and decreased oxidative damage. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury. Although MK is extensively used in Unani medicine, it lacks scientific grounds for its efficacy and to the best of our knowledge this is the first study to report its possible protective mechanisms against cerebral ischemic damage. One of the universally accepted etiologies of stroke is imbalance between factors of free radical formation and the maintenance of the neuronal integrity through the endogenous defense mechanism. In the present study, the major cellular defenses (both enzymatic and non enzymatic) were severely altered in the ischemic group as compared with the sham group, which was due to the increased formation of reactive oxygen species (ROS) and dwindling levels of the radical scavengers. However, this imbalance was prevented by MK supplementation. A substantial elevation in the LPO level and H2O2 content along with the depletion in the activity of various protective antioxidant enzymes in the ischemic brains which has been validated with immense earlier reports was observed [3, 4, 24, 25]. However, pre-treatment with MK resulted in the reversal of the increased LPO level, H2O2 content and up-regulated the depleted antioxidant enzymes when compared with the ischemic group suggesting the decreased formation of ROS or radical scavenging activity of MK after ischemic injury. Neuronal and cognitive impairments were seen to be improved after stroke with decoction of herbs (Gagamjungjihwan) and (Frustus Euodiae) and the Chinese herbal formula (FBD) by the restoration of GSH content and lowering the lipid peroxides during ischemic damage [26, 27]. 2ff7e9595c
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